Why the study?
Obesity is associated with substantial cardiovascular risk, and changes to the secretory profile of adipose tissue contribute to pathogenesis.
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Design
Review
Adipose-targeted therapies merit investigation in obesity-related disease; leaves open clinical translation pending interventional trials.
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.
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Saxton et al. (2019) studied this question.
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