Key result
Sodium reduction lowers systolic and diastolic BP in a linear, dose-dependent manner across all intakes.
Why the study?
Does sodium reduction reduce systolic and diastolic BP in participants of clinical trials?
Meta-Analysis
Does sodium reduction reduce systolic and diastolic BP in participants of clinical trials?
Dietary sodium reduction linearly decreases both systolic and diastolic blood pressure, with greater absolute reductions seen in individuals with higher baseline blood pressure.
Supports sodium reduction counseling across BP levels; reinforces linear dose-response evidence from aggregated trials.
In this dose-response analysis of sodium reduction in clinical trials, we identified an approximately linear relationship between sodium intake and reduction in both systolic and diastolic BP across the entire range of dietary sodium exposure. Although this occurred independently of baseline BP, the effect of sodium reduction on level of BP was more pronounced in participants with a higher BP level.
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Filippini et al. (2021) conducted a meta-analysis in Blood pressure. Sodium reduction was evaluated on Reduction in systolic and diastolic BP. Sodium reduction demonstrated an approximately linear relationship with reductions in systolic and diastolic blood pressure across all levels of dietary sodium exposure.
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