Why the study?
Does warfarin treatment improve survival in patients with paroxysmal atrial fibrillation?
Does warfarin treatment improve survival in patients with paroxysmal atrial fibrillation?
In patients with paroxysmal atrial fibrillation, who face increased mortality primarily due to cardiovascular risks, treatment with warfarin is associated with improved survival.
Should not yet change practice in PxAF; leaves open confirmation of survival benefit in RCTs.
PxAF is associated with increased mortality, which mostly appears to be related to concomitant cardiovascular risks. Treatment with warfarin is associated with improved survival in PxAF patients.
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Friberg et al. (2007) studied this question.