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April 1, 2026Journal of Dermatological ScienceOpen Access

A shift towards a type I immune response in chronic atopic dermatitis favours an IL-15 dependent tissue resident memory cell niche

Adewonuola Alase Caroline Mann Antonia Kolb Sakshi Vasant Wagle Matthias Klein Daniela Kramer Miriam Wittmann

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Key Points

The study aims to investigate the role of IL-15 in the chronic inflammation of atopic dermatitis (AD).
Primary human keratinocytes and fibroblasts were cultured to assess IL-15 expression and production through qPCR and ELISA.
RNA sequencing and PCR were conducted on lesional and nonlesional AD biopsies.
The impact of various cytokines and PAMPs on IL-15 induction was evaluated in fibroblasts and keratinocytes.
Keratinocytes primarily induced IL-15 in response to IFN, while fibroblasts reacted to prolonged IL-4 exposure.
Transcriptomic analyses revealed a correlation between IL-15, a higher IFN signature, and longer disease duration in AD biopsies.
Significant associations were noted between IL-15 and TRM markers CCR8 and CD69.

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Implication

Explores IL-15 in chronic atopic dermatitis, suggesting implications for flare interventions.

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Cite This Study

Alase et al. (2026) studied this question.

synapsesocial.com/papers/69f04e08727298f751e71fbf https://doi.org/10.1016/j.jdermsci.2026.04.004

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