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April 28, 2026Cardiovascular Research1 citations

Differential metabolomic prediction of outcomes in HFpEF and HFrEF: a prospective international multi-ethnic cohort study

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LWLik Hang WuNational University of SingaporeLPLeroy Sivappiragasam PakkiriNational University of SingaporeJTJasper Tromp

Key Points

  • This research aims to identify differential metabolic signatures associated with heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) to improve risk assessment and treatment strategies.
  • Prospective international multi-ethnic cohort study
  • Analysis of metabolic signatures associated with HFpEF and HFrEF
  • Focus on metabolic inflammation and energy metabolism pathways
  • Identified distinct metabolic profiles for HFpEF and HFrEF patients
  • Enhanced risk stratification based on metabolic signatures
  • Highlighted potential therapeutic targets for intervention

Abstract

Differential metabolic signatures tied to metabolic inflammation in HFpEF and impaired energy metabolism in HFrEF enhance risk stratification and point to therapeutic targets.

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69f04e9b727298f751e727a1https://doi.org/10.1093/cvr/cvag090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction2015 · 221 citations
  2. 2Untargeted Metabolomics Unveils Metabolic Biomarkers in HFpEF2025
  3. 3Untargeted metabolomics unveils metabolic biomarkers in HFpEF2025
  4. 4Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF2024 · 3 citations
  5. 5Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure2016 · 272 citations