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In vitro–in silico study reveals Vitamin B12 enhances gentamicin activity, while Vitamin D3 may reduce it.
Vitamin B12 represents a promising dose-sparing adjuvant for gentamicin, while vitamin D3 may compromise aminoglycoside efficacy under the tested conditions. These findings warrant further validation using clinical isolates and biofilm models before considering vitamin-based strategies in aminoglycoside stewardship.
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M’hamedi et al. (2026) studied this question.
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