Key result
Severely abnormal BMIPP SPECT predicts ~22-fold higher cardiac death risk in asymptomatic hemodialysis patients.
Why the study?
To evaluate the potential of 123I-BMIPP SPECT to predict cardiac death in chronic hemodialysis patients.
Population
375 asymptomatic chronic hemodialysis patients without prior MI or revascularization
Comparison
Severely abnormal BMIPP SPECT images vs less abnormal images
Design
Prospective cohort study
Follow-up
3.6 +/- 1.0 years
Authors
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Hypothesis-generating for BMIPP SPECT risk stratification in asymptomatic hemodialysis patients; prospective trials needed before clinical adoption.
Cohort (n=318)
Effect estimate: HR 21.894
Absolute Event Rate: 61% vs 98%
p-value: p=< 0.0001
Nishimura et al. (2008) conducted a cohort in Asymptomatic chronic hemodialysis (n=318). 123I-BMIPP SPECT (summed score ≥12) vs. 123I-BMIPP SPECT (summed score <12) was evaluated on Cardiac death (HR 21.894, p=< 0.0001). Severely abnormal BMIPP SPECT images (summed scores ≥12) strongly predicted cardiac death in asymptomatic hemodialysis patients (HR 21.894; p < 0.0001).
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