April 28, 2026Open Access

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

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Resumen

Pin1 drives diabetic vascular disease by causing mitochondrial oxidative stress, eNOS dysregulation as well as NF-kB-induced inflammation. These findings provide molecular insights for novel mechanism-based therapeutic strategies in patients with diabetes.

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Cite this study

Paneni et al. (Tue,) studied this question.

synapsesocial.com/papers/69f0cfedb606b7e8fdeb2f4a — DOI: https://doi.org/10.1093/eurheartj/ehu179

Authors

Francesco Paneni

Preventive Cardiology

Sarah Costantino

Heart Failure & Transplant

Lorenzo Castello

University of Milano-Bicocca

Journals

European Heart Journal

Actions

Institutions

Sapienza University of Rome

Karolinska University Hospital

University Hospital of Zurich

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion