Adipose tissue in health and disease

Figure 1.. General classifications of metabolically healthy and unhealthy white adipose tissue (AT). Metabolically healthy AT is generally stored subcutaneously, is highly vascularized with low levels of macrophages and has appropriate adiponectin secretion. Healthy adipocytes also have less production and secretion of leptin and resistin. Healthy adipocytes are insulin sensitive with low basal lipolysis that is associated with overall systemic metabolic health. In contrast, metabolically compromised AT is primarily stored in the visceral cavity, has reduced vascularity with increased infiltration or presence of proinflammatory macrophages, and enhanced secretion of leptin and resistin. Typically, unhealthy adipocytes are insulin resistant and have increased basal lipolysis. The increased fatty acids from lipolysis contribute to systemic metabolic dysfunction.

Figure 2.. Contribution of adipose tissue dysfunction in the perpetuation of metabolic disease. Disturbances in lipid storage, such as in obesity or lipodystrophy, will interfere with proper adipocyte function and can contribute to insulin resistance. Insulin resistance within the adipose tissue will disrupt normal adipocyte signalling and metabolism resulting in elevated lipolysis. Chronically elevated circulating lipids can lead to ectopic lipid storage and insulin resistance in other tissues, including skeletal muscle and liver. Insulin resistance in the liver in particular is problematic as insulin signalling tightly regulates hepatic glucose production. All of these events can have significant consequences on metabolic health, ultimately resulting in a vicious cycle that perpetuates systemic metabolic disorder.