Do BNP and NT-proBNP enhance risk prediction of cardiovascular outcomes in patients with a recent acute coronary syndrome and type 2 diabetes mellitus?
In patients with recent ACS and type 2 diabetes, BNP and NT-proBNP are powerful predictors of cardiovascular outcomes including MI, stroke, and death, providing as much predictive information for mortality as all other conventional variables combined.
BACKGROUND: Natriuretic peptides are recognized as important predictors of cardiovascular events in patients with heart failure, but less is known about their prognostic importance in patients with acute coronary syndrome. We sought to determine whether B-type natriuretic peptide (BNP) and N-terminal prohormone B-type natriuretic peptide (NT-proBNP) could enhance risk prediction of a broad range of cardiovascular outcomes in patients with acute coronary syndrome and type 2 diabetes mellitus. METHODS AND RESULTS: <0.001). BNP or NT-proBNP alone predicted death as well as all other variables combined (0.77 versus 0.77). CONCLUSIONS: In patients with a recent acute coronary syndrome and type 2 diabetes mellitus, BNP and NT-proBNP were powerful predictors of cardiovascular outcomes beyond heart failure and death, ie, were also predictive of MI and stroke. Natriuretic peptides added as much predictive information about death as all other conventional variables combined. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01147250.
Wolsk et al. (Tue,) studied this question.