Why the study?
Does a combination of low-intensity, fixed-dose warfarin and aspirin reduce ischaemic stroke and systemic embolism compared to adjusted-dose warfarin in high-risk patients with atrial fibrillation?
Population
1044 patients with non-valvular atrial fibrillation and at least one thromboembolic risk factor
Comparison
Combination of low-intensity, fixed-dose… vs Adjusted-dose warfarin (target INR 2.0-3.0)
Design
RCT, Randomly assigned, Open-labelled
Follow-up
mean 1.1 years
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Avoid low-intensity warfarin plus aspirin in high-risk AF; confirms adjusted-dose warfarin superiority for stroke prevention.
Does a combination of low-intensity, fixed-dose warfarin and aspirin reduce ischaemic stroke and systemic embolism compared to adjusted-dose warfarin in high-risk patients with atrial fibrillation?
Low-intensity, fixed-dose warfarin plus aspirin is inferior to adjusted-dose warfarin for stroke prevention in high-risk patients with atrial fibrillation.
A 1996 study studied this question.
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