Why the study?
Does a combination of low-intensity, fixed-dose warfarin and aspirin reduce ischaemic stroke and systemic embolism compared to adjusted-dose warfarin in high-risk patients with atrial fibrillation?
Does a combination of low-intensity, fixed-dose warfarin and aspirin reduce ischaemic stroke and systemic embolism compared to adjusted-dose warfarin in high-risk patients with atrial fibrillation?
Low-intensity, fixed-dose warfarin plus aspirin is inferior to adjusted-dose warfarin for stroke prevention in high-risk patients with atrial fibrillation.
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Avoid low-intensity warfarin plus aspirin in high-risk AF; confirms adjusted-dose warfarin superiority for stroke prevention.
A 1996 study studied this question.
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