Polygenic prediction of cardiorespiratory fitness: The HUNT Study

Figures

• 

  Figure 1.. Cardiorespiratory fitness for each decile of the CRFPGS at HUNT3 and HUNT4 CRFPGS, polygenic risk score for cardiorespiratory fitness; HUNT, the Trøndelag Health Study. Data presented as mean with 95% confidence intervals for each decile.

• 

  Figure 2.. Cardiovascular disease risk CRFPGS, polygenic risk score for cardiorespiratory fitness; CI, confidence interval, SD; standard deviation. Disease outcomes were obtained from hospital records spanning January 1999 through March 2020 in participants from the Trøndelag Health Study that were not included in the base data (HUNT; n = 82 109). The models were adjusted for the first ten principal components with age as the time scale.

• 

  Figure 3.. Odds of hyperglycemia and use of lipid-lowering and blood pressure drugs CRFPGS, polygenic risk score for cardiorespiratory fitness; CI, confidence interval; SD, standard deviation. The models were adjusted for age, age2, and the first ten principal components. The outcomes are derived from questionnaires distributed to participants in the latest Trøndelag Health Study (HUNT) survey (HUNT4) that were not included in the base data. The phrasing of each questionnaire item is available in the supplementary material.