June 15, 1995Circulation
Absence of Lethal Reperfusion Injury After 3 Hours of Reperfusion
Why the study?
Does reperfusion for 3 hours cause lethal reperfusion injury (increased necrosis) compared to ischemia alone in a canine model?
Population
14 anesthetized, open-chest dogs in a single-canine-heart model of ischemia-reperfusion
Comparison
Reperfusion for 3 hours after 90 to 180 minutes… vs Identical period of ischemia without reperfusion
Design
Preclinical
Follow-up
3 hours
Authors
Discussion
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Member takes
Implication
No added necrosis from 3-hour reperfusion in canines; challenges lethal reperfusion injury but leaves open human relevance.
Structured PICO
Does reperfusion for 3 hours cause lethal reperfusion injury (increased necrosis) compared to ischemia alone in a canine model?
P
Population
14 anesthetized, open-chest dogs in a single-canine-heart model of ischemia-reperfusion
I
Intervention
Reperfusion for 3 hours after 90 to 180 minutes of ischemia (distal LAD region)
C
Comparator
Identical period of ischemia without reperfusion (proximal LAD region in the same heart)
O
Outcome
Transmurality of necrosis (measured as % of left ventricular wall thickness)surrogate
In a canine model of ischemia-reperfusion, 3 hours of reperfusion did not increase the transmural extent of necrosis, challenging the existence of lethal reperfusion injury.
Cite This Study
Zahger et al. (1995) studied this question.