Population
HEK 293 cells with stable and transient expression of wild type HERG and LQT-2 mutations
Comparison
LQT-2 mutations vs Wild type HERG
Design
Preclinical
Authors
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Distinct HERG mutation mechanisms in LQT2 extend mechanistic insight; hypothesis-generating from animal data, clinical translation remains open.
The loss of HERG channel function in LQT-2 syndrome is driven by multiple distinct molecular mechanisms, including abnormal processing, generation of nonfunctional channels, and altered gating.
Zhou et al. (1998) studied this question.