August 1, 1994Cardiovascular Research

Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart

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Why the study?

Does ranolazine improve haemodynamic and biochemical markers of reperfusion injury in an isolated rabbit heart model of ischaemia and reperfusion?

Structured PICO

Does ranolazine improve haemodynamic and biochemical markers of reperfusion injury in an isolated rabbit heart model of ischaemia and reperfusion?

Population

Isolated hearts from male New Zealand White rabbits perfused in the Langendorff mode

Intervention

Ranolazine (10 or 20 microM) administered for 10 min before exposure to a 30 min period of global ischaemia and 60 min reperfusion

Comparator

Vehicle control and a normoxic control group

Outcome

Haemodynamic variables (left ventricular pressure), myocardial creatine kinase, and potassium releasesurrogate

Ranolazine demonstrated significant cardioprotective properties, including improved hemodynamics and reduced cellular injury, in an isolated rabbit heart model of ischemia-reperfusion.

Discussion

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Implication

Ranolazine shows cardioprotection in rabbit hearts; hypothesis-generating and leaves open translation to clinical reperfusion injury.

Cite This Study

Gralinski et al. (1994) studied this question.

synapsesocial.com/papers/69f14bad2811130d0cde228e https://doi.org/10.1093/cvr/28.8.1231

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