Why the study?
Does ranolazine improve metabolic parameters and preserve tissue ATP in isolated guinea-pig hearts during low-flow ischaemia?
Does ranolazine improve metabolic parameters and preserve tissue ATP in isolated guinea-pig hearts during low-flow ischaemia?
Ranolazine exerts protective metabolic effects in isolated guinea-pig hearts during low-flow ischaemia, preserving ATP and active pyruvate dehydrogenase.
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ATP preservation in guinea-pig ischaemia is hypothesis-generating; leaves open clinical translation to human myocardium.
Clarke et al. (1993) studied this question.
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