Key Points
- To update the 1994 International Task Force diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) to improve sensitivity for detecting early and familial disease while maintaining high specificity.
- Assessed structural, histological, electrocardiographic, arrhythmic, and genetic markers associated with ARVC/D (ClinicalTrials.gov: NCT00024505).
- Formulated quantitative diagnostic thresholds by comparing patient abnormalities with reference values from normal control subjects.
- Incorporated modern diagnostic imaging modalities and genetic testing into revised major and minor diagnostic criteria categories.
- Established quantitative criteria to improve sensitivity for early-stage and familial ARVC/D while maintaining specificity against disease phenocopies.
Structured PICO
PPopulationPatients suspected of having arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D)
IInterventionModified Task Force Criteria for ARVC/D diagnosis
OOutcomeDiagnostic sensitivity and specificity
The modified Task Force Criteria provide an updated, quantitative framework incorporating genetic and imaging advances to improve the diagnosis of ARVC/D.