Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock*

Kimberly Fenton; Craig Sable; Michael J. Bell; Kantilal M. Patel; John Berger

doi:10.1097/01.pcc.0000144711.97646.0c

November 1, 2004Pediatric Critical Care Medicine

Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock*

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Why the study?

Is elevated serum troponin I associated with cardiac dysfunction and disease severity in pediatric patients with septic shock?

Structured PICO

Is elevated serum troponin I associated with cardiac dysfunction and disease severity in pediatric patients with septic shock?

P

Population

23 pediatric patients with septic shock and cardiovascular failure

C

Comparator

Patients with normal troponin I

O

Outcome

Correlation of admission serum troponin I with echocardiographic measures of cardiac dysfunction (left ventricular ejection fraction, systolic fractional shortening, heart rate corrected mean velocity of circumferential fiber shortening, and end-systolic wall stress) and disease severity (Pediatric Risk of Mortality III, organ system failures)surrogate

In pediatric patients with septic shock, elevated admission troponin I is a useful biomarker that correlates with early myocardial systolic dysfunction and overall severity of illness.

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Implication

May support troponin monitoring for myocardial dysfunction in pediatric septic shock; hypothesis-generating and requires prospective validation.

Abstract

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Discussion

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Cite This Study

Fenton et al. (2004) studied this question.

synapsesocial.com/papers/69f14bfac0d8017361865b95 https://doi.org/10.1097/01.pcc.0000144711.97646.0c

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Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock*

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock*

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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