Does the presence of atrial fibrillation increase the risk of ventricular arrhythmias, sick sinus syndrome, and stroke in patients with non-high-risk Brugada syndrome?
In patients with non-high-risk Brugada syndrome, atrial fibrillation is associated with a significantly higher risk of sick sinus syndrome and stroke, while early-onset AF (<20 years) identifies a subgroup at elevated risk for ventricular arrhythmias.
BACKGROUND: Atrial fibrillation (AF) occurs in up to 20% of patients with Brugada syndrome (BrS), yet its risk factors and prognostic implications remain uncertain. OBJECTIVES: This study sought to identify risk factors for AF in patients with non-high-risk BrS and to evaluate the impact of AF on ventricular arrhythmias (VAs), sick sinus syndrome (SSS), and stroke in non-high-risk BrS. METHODS: This was a multicenter, retrospective study conducted across 20 international centers. Non-high-risk BrS patients were stratified based on the presence or absence of AF. The primary endpoint was the occurrence of VAs, defined as sustained ventricular tachycardia, ventricular fibrillation, or arrhythmic sudden cardiac death. RESULTS: -VA (mean 0.5). CONCLUSIONS: The presence of AF in non-high-risk BrS does not identify patients with higher risk of VAs. However, early-onset AF (<20 years) defines a distinct subgroup with elevated risk. Patients with AF and BrS have a significantly higher risk of SSS and stroke.
Bergonti et al. (Wed,) studied this question.
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