December 1, 2001Acta Cardiologica

C-reactive protein and paroxysmal atrial fibrillation

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Why the study?

Is elevated C-reactive protein associated with paroxysmal atrial fibrillation and failure of pharmacological cardioversion?

Population

100 subjects: 50 patients with recent onset paroxysmal atrial fibrillation and 50 age- and sex-matched…

Comparison

Measurement of C-reactive protein levels; PAF… vs Age and sex matched controls with normal sinus…

Design

Case-control

Follow-up

24 hours

Authors

JDJohn DernellisNational and Kapodistrian University of Athens MPMaria PanaretouSt. Mary’s Hospital

Discussion

Member takes

Implication

May support CRP to flag cardioversion failure risk in PAF; hypothesis-generating and needs prospective validation before practice change.

Structured PICO

Is elevated C-reactive protein associated with paroxysmal atrial fibrillation and failure of pharmacological cardioversion?

Population

100 subjects: 50 patients with recent onset paroxysmal atrial fibrillation (<24 h) and 50 age- and sex-matched controls with normal sinus rhythm. Excluded: thyrotoxicosis, mitral stenosis, pulmonary emboli, or pericarditis.

Intervention

Measurement of C-reactive protein (CRP) levels; PAF patients received amiodarone (2.7 g over 24 hours) for pharmacological cardioversion.

Comparator

Age and sex matched controls with normal sinus rhythm.

Outcome

CRP levels in PAF patients versus controls, and successful cardioversion to normal sinus rhythm within 24 hours.surrogate

Elevated CRP levels are strongly associated with paroxysmal atrial fibrillation and predict failure of pharmacological cardioversion with amiodarone.

Cite This Study

Dernellis et al. (2001) studied this question.

synapsesocial.com/papers/69f14cceb5f6a2886736eccc https://doi.org/10.2143/ac.56.6.2005701

Topics

Persistent AF management Atrial fibrillation

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