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April 27, 2026Microbial Drug Resistance

Association of katG , inhA, and AhpC Mutations with Isoniazid Resistance of Mycobacterium tuberculosis in Pulmonary Tuberculosis Patients from Nanjing, China

Y F Yang Ying Liu Yan Huang Yulan Niu Kong Jun Li Zhang

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Key Points

To assess the relationship between specific gene mutations and isoniazid resistance in Mycobacterium tuberculosis.
Analyzed mutations in katG, inhA, and AhpC genes.
Investigated isoniazid resistance in strains from pulmonary tuberculosis patients.
Conducted the study in a population from Nanjing, China.
Identified specific mutations associated with isoniazid resistance in Mycobacterium tuberculosis strains.
Mutation presence correlated with increased resistance levels.

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Implication

Analysis reveals isoniazid resistance in Mycobacterium tuberculosis from TB patients in Nanjing, indicating genetic mutations may play a role.

Abstract

strains in TB patients from Nanjing, China.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69f15432879cb923c49445b2 https://doi.org/10.1177/10766294261446052

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The impact of combined gene mutations in <i>inhA</i> and <i>ahpC</i> genes on high levels of isoniazid resistance amongst <i>katG</i> non-315 in multidrug-resistant tuberculosis isolates from ChinaOriginal Research · 2018 · 48 citations
2Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis: A Systematic ReviewSystematic Review · 2015 · 327 citations
3Prevalence and resistance spectrum of <i>ahpC</i> mutations in isoniazid-resistant <i>Mycobacterium tuberculosis</i> isolatesOriginal Research · 2026
4Prevalence of<i>katG</i>and<i>inhA</i>mutations in genes associated with isoniazid resistance in<i>Mycobacterium tuberculosis</i>clinical isolates in Cameroon2024
5Discovery and Functional Characterization of katG Mutations Mediating Isoniazid Resistance in Mycobacterium tuberculosisOriginal Research · 2026

Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon2025
Screening and Characterization of Mutations in Isoniazid-Resistant <i>Mycobacterium tuberculosis</i> Isolates Obtained in Brazil2004
Detection of Isoniazid-Resistant <i>Mycobacterium tuberculosis</i> Strains by a Multiplex Allele-Specific PCR Assay Targeting <i>katG</i> Codon 315 Variation2002
Combating Porcine-Origin Multidrug-Resistant Staphylococcus aureus with a Traditional Chinese Medicine: In Vitro Efficacy and Mechanistic InsightsMicrobial Drug Resistance · 2026
Co-occurrence of bla NDM-5 and mcr-1 on Two Distinct, Independently Transferable Plasmids in Commensal Escherichia coli ST156 from a Healthy Companion DogMicrobial Drug Resistance · 2026

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