Association of katG , inhA, and AhpC Mutations with Isoniazid Resistance of Mycobacterium tuberculosis in Pulmonary Tuberculosis Patients from Nanjing, China

Key Points

• To assess the relationship between specific gene mutations and isoniazid resistance in Mycobacterium tuberculosis.
• Analyzed mutations in katG, inhA, and AhpC genes.
• Investigated isoniazid resistance in strains from pulmonary tuberculosis patients.
• Conducted the study in a population from Nanjing, China.
• Identified specific mutations associated with isoniazid resistance in Mycobacterium tuberculosis strains.
• Mutation presence correlated with increased resistance levels.