Bacterial-derived C6-HSL enhances disease resistance and lignin synthesis in apples, indicating MdWRKY22's regulatory role.
. DNA affinity purification sequencing (DAP-seq) and luciferase (LUC) assay revealed that MdWRKY22 binds to the promoter of apple mannitol dehydrogenase (MdMTD) and activates its transcription. The apple transient transformation experiment indicates that MdMTD has a negative regulatory effect on lignin biosynthesis and disease resistance. Collectively, C6-HSL reduces the transcription of MdMTD by degrading MdWRKY22, thereby enhancing the accumulation of lignin and disease resistance in apple.
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Wang et al. (2026) studied this question.
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