Multivariable analysis reveals tumour microenvironment factors impact prognosis in canine pulmonary adenocarcinomas, suggesting enhanced risk stratification.
, respectively. Tumours with LAs showed higher CD20+ and Foxp3+ cell densities than tumours without LAs. Median PFI and OST were 754 days (95% CI, 375-not reached) and 716 days (95% CI, 399-936), respectively. In multivariable analysis, tumour size classification, lymph node metastasis, surgical margin status and the presence of LAs were independently associated with shorter PFI. Age, lymph node metastasis and the CD8/Foxp3 ratio were independently associated with OST. These findings indicate that immunohistochemical features may provide additional prognostic information for postoperative risk stratification in cPACs and complement established clinicopathological factors.
No takes yet. Share an insight, caveat, or question.
Ichimata et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: