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April 29, 2026Advanced Engineering Materials

Photodynamically Active Zinc‐Phthalocyanine Loaded Mesoporous Bioactive Glass Nanoparticles for Biomedical Applications

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Authors

FKFatih KurtulduOŞOrhan ŞişmanGGGustavo Galleani

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Overview

Photodynamic therapy reduces cell viability in Galleria mellonella using biodegradable nanoparticles, suggesting potential for infection control.

Key Points

  • The research aims to develop nanoparticles for enhanced photodynamic therapy to treat infections and cancer.
  • Loaded zinc phthalocyanine into mesoporous bioactive glass nanoparticles.
  • Analyzed structure using scanning electron microscopy and transmission electron microscopy.
  • Conducted in vitro and in vivo tests to assess cytotoxicity and antimicrobial activity.
  • Nanoparticles retained bioactivity after exposure to body fluid.
  • Post-irradiation, nanoparticles showed significant antimicrobial activity against S. aureus at 50 µg/mL.
  • Demonstrated biocompatibility in Galleria mellonella model at the same concentration.

Cite This Study

Kurtuldu et al. (2026) studied this question.

synapsesocial.com/papers/69f154c0879cb923c4944f84https://doi.org/10.1002/adem.202501775
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