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April 29, 2026RSC AdvancesOpen Access

Novel piperazine–triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis

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Authors

MHMuhammad HaroonSKShagufta KamalAMAsim Mansha

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Overview

Demonstrates effective synthesis of piperazine derivatives as PTP1B and alpha-amylase inhibitors, indicating potential therapeutic benefits.

Key Points

  • To evaluate novel piperazine–triazole hybrids as inhibitors of PTP1B and alpha-amylase.
  • Synthesis of piperazine–triazole hybrids.
  • Biological evaluation of inhibition effects in vitro.
  • Computational validation using network pharmacology and molecular docking.
  • Identified piperazine derivatives as effective inhibitors of alpha-amylase and PTP1B.
  • Supported findings with MD simulations and DFT analysis.

Cite This Study

Haroon et al. (2026) studied this question.

synapsesocial.com/papers/69f154e0879cb923c4945227https://doi.org/10.1039/d6ra00931j
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