Key result
Vascular lesion morphology fundamentally governs drug retention and response in cardiovascular drug delivery systems.
Why the study?
Enthusiasm for drug-eluting cardiovascular devices has sometimes exceeded demonstration of efficacy and understanding of mechanisms, motivating an examination of how lesion morphology governs drug retention and response.
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Should not yet alter clinical drug delivery decisions; leaves open prospective trials for morphology-guided personalization.
Marlevi et al. (2021) conducted a review in Cardiovascular disease. Drug delivery systems (drug-eluting stents, bioresorbable scaffolds, drug-coated balloons) was evaluated. Vascular lesion morphology, including lipid content, calcium, and thrombus, fundamentally governs drug retention and response in cardiovascular drug delivery systems.
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