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April 29, 2026Journal of the American College of Cardiology

Diagnostic Accuracy of Angiography-Based Quantitative Flow Ratio Measurements for Online Assessment of Coronary Stenosis

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Key result

Online quantitative flow ratio (QFR) achieved a patient-level diagnostic accuracy of 92.4% (95% CI: 88.9% to 95.1%; p<0.001) for identifying hemodynamically significant coronary stenosis.

Authors

BXBo XuSTShengxian TuSQShubin Qiao

Discussion

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Overview

May support wire-free QFR for physiologic lesion assessment; leaves open outcome impact pending randomized trials.

Study Design

Type

Observational (n=308)

Blinding

Blinded

Multicenter

Yes

PICO

P
Population
Coronary stenosis (n=308)
I
Intervention / Comparator
Quantitative flow ratio (QFR) vs Quantitative coronary angiography (QCA) and wire-based FFR
O
Primary Outcome
Diagnostic accuracy of QFR exceeding a lower 95% CI boundary of 75% (88.9% to 95.1%), p=< 0.001

Main Result

p-value: p=< 0.001

Cite This Study

Xu et al. (2017) conducted an observational in Coronary stenosis (n=308). Quantitative flow ratio (QFR) vs. Quantitative coronary angiography (QCA) and wire-based FFR was evaluated on Diagnostic accuracy of QFR exceeding a lower 95% CI boundary of 75% (95% CI 88.9% to 95.1%, p=< 0.001). Online quantitative flow ratio (QFR) achieved a patient-level diagnostic accuracy of 92.4% (95% CI: 88.9% to 95.1%; p<0.001) for identifying hemodynamically significant coronary stenosis.

synapsesocial.com/papers/69f178a3adb7394e289b48a2https://doi.org/10.1016/j.jacc.2017.10.035
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