Why the study?
Does eritoran reduce cardiac hypertrophy in mice after transverse aortic constriction?
Population
C57BL/6 mice undergoing transverse aortic constriction (TAC) or sham surgery
Comparison
Eritoran administered via jugular vein catheter vs Placebo
Design
Preclinical
Follow-up
3 days
Authors
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Eritoran attenuated hypertrophy in this murine TAC model; leaves open translation of TLR4 antagonism to human pressure-overload states.
Does eritoran reduce cardiac hypertrophy in mice after transverse aortic constriction?
The TLR4 antagonist eritoran attenuates the development of cardiac hypertrophy and modulates inflammatory cytokines in a murine model of pressure overload.
Ehrentraut et al. (2011) studied this question.
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