August 5, 2003Circulation
Intra-Atrial Pressure Increases Rate and Organization of Waves Emanating From the Superior Pulmonary Veins During Atrial Fibrillation
Why the study?
Does elevation of intra-atrial pressure increase the rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation in a sheep model?
Population
9 sheep hearts using a stretch-related AF model to induce stable episodes of AF (>40 minutes)
Comparison
Elevation of intra-atrial pressure (>10 cm H2O) vs Intra-atrial pressure <10 cm H2O
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Atrial stretch may promote organized PV drivers in AF; leaves open human mechanistic relevance and therapeutic targeting.
Structured PICO
Does elevation of intra-atrial pressure increase the rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation in a sheep model?
P
Population
9 sheep hearts using a stretch-related AF model to induce stable episodes of AF (>40 minutes)
I
Intervention
Elevation of intra-atrial pressure (>10 cm H2O)
C
Comparator
Intra-atrial pressure <10 cm H2O
O
Outcome
Maximum dominant frequency (DFMax) in the LA superior pulmonary vein junction (JPV) and LA free wall (LAFW), and spatio-temporal organization of wavessurrogate
Elevation of intra-atrial pressure increases the rate and organization of waves emanating from the superior pulmonary veins, providing a mechanistic explanation for stretch-related atrial fibrillation.
Cite This Study
Kalifa et al. (2003) studied this question.