Why the study?
Following FDA approval for infarct size reduction, the longer-term clinical outcomes of supersaturated oxygen therapy after pPCI in anterior STEMI remained to be determined.
Does supersaturated oxygen therapy improve 1-year clinical outcomes in patients with anterior STEMI after pPCI?
Population
Patients with anterior STEMI after pPCI
Comparison
Supersaturated oxygen therapy infusion vs propensity-matched controls from the INFUSE-AMI trial
Design
Propensity-matched comparative study
Follow-up
1-year
Authors
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Should not yet change pPCI practice in anterior STEMI; leaves open confirmation of supersaturated oxygen benefit in randomized trials.
Does supersaturated oxygen therapy improve 1-year clinical outcomes in patients with anterior STEMI after pPCI?
Supersaturated oxygen therapy following pPCI in anterior STEMI is associated with improved 1-year clinical outcomes, including lower rates of death and heart failure.
Chen et al. (2020) studied this question.
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