Randomized trial demonstrates insulin resistance's role in lung function impairment due to obesity-related factors, suggesting metabolic interventions are needed.
Key Points
This research examines the role of insulin resistance in the association between visceral adiposity and preserved ratio impaired spirometry.
Analyzed data from 4979 adults in NHANES
Used multivariable logistic regression and mediation analyses
Evaluated associations using visceral adiposity index, lipid accumulation product, waist-to-height ratio, and HOMA-IR
Higher visceral adiposity index, lipid accumulation product, and waist-to-height ratio associated with increased likelihood of PRISm; all p < 0.01
Elevated HOMA-IR linked to PRISm; Q4 vs Q1: OR = 2.27, 95% CI 1.46–3.52
Insulin resistance explained 9.2–32.8% of the associations between adiposity indices and PRISm