This research investigates how variations in the APOL1 gene contribute to higher risks of nephropathy and end-stage renal disease in individuals of African ancestry.
Analyzed genetic variations in the APOL1 gene among different populations.
Evaluated the association of these variations with end-stage renal disease susceptibility.
Individuals with specific APOL1 gene variants showed a significantly higher risk of developing end-stage renal disease compared to those without these variants.
Abstract
The increased susceptibility to end-stage renal disease (ESRD) in individuals of African ancestry is influenced by variations in the APOL1 gene.