Collective Behavior of Silica Nanoparticle Assemblies Governs Translocation Across Pulmonary Surfactant: From Synergistic Effects to Inhalation Toxicity

唐开亮; Honglin Hang; Haiwen Ge; Zhongnan An; Xinguang Cui

doi:10.1021/acs.langmuir.6c00061

April 27, 2026Langmuir

Collective Behavior of Silica Nanoparticle Assemblies Governs Translocation Across Pulmonary Surfactant: From Synergistic Effects to Inhalation Toxicity

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Key Points

This research aims to link the architecture of silica nanoparticles to their ability to translocate across pulmonary surfactant and disrupt monolayers.
Developed a systematic simulation framework to analyze multi-nanoparticle architectures and their behaviors.
Examined translocation dynamics and pulmonary surfactant (PS) interaction through simulation studies.
Silica nanoparticles significantly inhibit monolayer penetration, affecting their translocation across pulmonary surfactant.
Findings suggest a relationship between nanoparticle architecture and inhalation toxicity, potentially guiding future studies.

Implication

Simulations explore how silica nanoparticles affect pulmonary surfactant, indicating implications for inhalation toxicity research.

Abstract

NPs dominate the overall behavior and significantly inhibit monolayer penetration. This work provides a systematic simulation framework for relating multi-NP architecture to translocation and PS disruption and may help generate testable hypotheses to guide future inhalation toxicology studies and nanomaterial research.

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Cite This Study

唐开亮 et al. (2026) studied this question.

synapsesocial.com/papers/69f19f9cedf4b46824806689 https://doi.org/10.1021/acs.langmuir.6c00061

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Collective Behavior of Silica Nanoparticle Assemblies Governs Translocation Across Pulmonary Surfactant: From Synergistic Effects to Inhalation Toxicity

Key Points

Implication

Abstract

Discussion

Cite This Study

Collective Behavior of Silica Nanoparticle Assemblies Governs Translocation Across Pulmonary Surfactant: From Synergistic Effects to Inhalation Toxicity

Key Points

Implication

Abstract

Discussion

Cite This Study

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