Do native T1, T2, and ECV mapping improve diagnostic performance compared to Lake Louise Criteria in patients with suspected acute myocarditis?
Native T1, T2, and ECV mapping provide comparable diagnostic performance to the Lake Louise Criteria for detecting acute myocarditis, with native T1 offering significantly better sensitivity.
BACKGROUND: The Lake Louise Criteria (LLC) were established in 2009 and are the recommended cardiac magnetic resonance imaging criterion for diagnosing patients with suspected myocarditis. Subsequently, newer parametric imaging techniques which can quantify T1, T2, and the extracellular volume (ECV) have been developed and may provide additional utility in the diagnosis of myocarditis. However, whether their diagnostic accuracy is superior to LLC remains unclear. In this meta-analysis, we compared the diagnostic performance of native T1, T2, ECV to LLC in diagnosing acute myocarditis. METHODS AND RESULTS: =0.025). Otherwise, there was no significant difference in sensitivity, specificity, and diagnostic odds ratio when comparing LLC to native T1, T2, or ECV. CONCLUSIONS: Native T1, T2, and ECV mapping provide comparable diagnostic performance to LLC. Although only native T1 had significantly better sensitivity than LLC, each technique offers distinct advantages for evaluating and characterizing myocarditis when compared with the LLC.
Pan et al. (Sun,) studied this question.
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