Design
Mendelian randomization and genetic correlation study
Hypothesis-generating for heart-brain links; leaves open causal validation before any clinical consideration.
) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.
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Zhao et al. (2023) studied this question.
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