May 21, 2008Annals of Neurology131 citationsOpen Access
View Full PaperCystatin C as a marker of cognitive function in elders: Findings from the health ABC study
Structured PICO
Is high serum cystatin C associated with cognitive impairment and decline in elders?
P
Population
3,030 elders
I
Intervention
High serum cystatin C
C
Comparator
Intermediate/low serum cystatin C
O
Outcome
Cognition (baseline scores and incident cognitive impairment measured by Modified Mini-Mental State Examination or Digit Symbol Substitution Test)surrogate
High serum cystatin C is associated with worse baseline cognitive function and greater incident cognitive decline in older adults.
Abstract
We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain beta-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p or=1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).