April 28, 2000Circulation Research

Remodeling of Gap Junctional Coupling in Hypertrophied Right Ventricles of Rats With Monocrotaline-Induced Pulmonary Hypertension

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Population

Rats with monocrotaline (MCT)-induced pulmonary hypertension and hypertrophied right ventricles

Comparison

Monocrotaline treatment to induce pulmonary… vs Control rats

Design

Preclinical

Follow-up

2 and 4 weeks

Authors

MUMahmud UzzamanKhulna Medical College HHHaruo HonjoHealth Promotion Agency YTYoshiko TakagishiNagoya University

Discussion

Member takes

Implication

Altered RV conduction in this hypertrophy model should not change practice; leaves open whether anisotropic changes promote arrhythmias in human pressure overload.

Structured PICO

Population

Rats with monocrotaline (MCT)-induced pulmonary hypertension and hypertrophied right ventricles

Intervention

Monocrotaline (MCT) treatment to induce pulmonary hypertension

Comparator

Control rats

Outcome

Remodeling of gap junctional organization (Cx43 labeling) and anisotropic conduction propertiessurrogate

Right ventricular hypertrophy induced by pressure overload in a rat model is associated with disorganized gap junction distribution and altered anisotropic conduction properties.

Cite This Study

Uzzaman et al. (2000) studied this question.

synapsesocial.com/papers/69f29cbe1b51e2fbf01871e9 https://doi.org/10.1161/01.res.86.8.871

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Implication

Altered RV conduction in this hypertrophy model should not change practice; leaves open whether anisotropic changes promote arrhythmias in human pressure overload.