Population
Isolated heart cells
Comparison
Beta-adrenergic receptor stimulation and direct… vs Baseline state and simultaneous muscarinic…
Design
Preclinical
Authors
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Hypothesis-generating for autonomic control of cardiac electrophysiology; leaves open relevance to intact hearts or human arrhythmias.
Demonstrates the existence of an autonomic-regulated, cAMP-dependent chloride current in isolated heart cells that modulates action potential duration and resting membrane potential.
Harvey et al. (1989) studied this question.
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