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January 1, 1988Circulation ResearchOpen Access

Adrenergic modulation of the transient outward current in isolated canine Purkinje cells.

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Why the study?

Does norepinephrine modulate the transient outward current in isolated canine Purkinje cells?

Population

Single canine Purkinje cells

Comparison

Norepinephrine (concentrations > 10 M)… vs Baseline/control conditions (Ca2+-free conditions)

Design

Preclinical

Authors

TNTakahiro NakayamaOsaka International Cancer InstituteHFHarry A. FozzardUniversity of Vermont

Discussion

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Overview

Supports beta-adrenergic Ito modulation in canine Purkinje cells; leaves open clinical relevance for human repolarization.

Structured PICO

Does norepinephrine modulate the transient outward current in isolated canine Purkinje cells?

P
Population
Single canine Purkinje cells
I
Intervention
Norepinephrine (concentrations > 10(-9) M), beta-antagonist sotalol, forskolin, and increased intracellular cAMP
C
Comparator
Baseline/control conditions (Ca2+-free conditions)
O
Outcome
Transient outward current (inactivation kinetics and amplitude)surrogate

Norepinephrine modulates the transient outward current in cardiac Purkinje cells via beta-adrenergic receptor activation and cAMP, suggesting a role for neurotransmitter regulation of cardiac repolarization.

Cite This Study

Nakayama et al. (1988) studied this question.

synapsesocial.com/papers/69f29cbe1b51e2fbf01871f5https://doi.org/10.1161/01.res.62.1.162
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The ionic basis of concentration‐related effects of noradrenaline on the action potential of calf cardiac purkinje fibres.1982 · 146 citations
  2. 2Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.1981 · 1,671 citations