Why the study?
Does intracoronary nitroglycerin alleviate pacing-induced angina in patients undergoing cardiac catheterization?
Does intracoronary nitroglycerin alleviate pacing-induced angina in patients undergoing cardiac catheterization?
The antianginal effect of nitroglycerin is primarily mediated by systemic hemodynamic changes rather than direct coronary vasodilation, as intracoronary administration failed to relieve pacing-induced angina.
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Supports systemic over direct coronary mechanisms for nitroglycerin antianginal action; hypothesis-generating pending randomized confirmation.
Ganz et al. (1972) studied this question.