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September 1, 1988The Journal of PhysiologyOpen Access

Calcium‐activated non‐selective cation channel in ventricular cells isolated from adult guinea‐pig hearts.

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Population

Ventricular cells dissociated from adult guinea-pig hearts using collagenase

Design

Preclinical

Authors

TETsuguhisa EharaKyushu UniversityANAkinori NomaElectrophysiologyKOKyoichi OnoAkita University

Discussion

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Implication

May underlie transient inward currents in Ca2+-overloaded myocytes; leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
Ventricular cells dissociated from adult guinea-pig hearts using collagenase
I
Intervention
Exposure to varying intracellular free Ca2+ concentrations and different cation solutions (Na+-free Tyrode, Na+-rich, K+-rich, Li+-rich, Cs+-rich)
O
Outcome
Electrophysiological properties of Ca2+-activated non-selective cation channels (conductance, reversal potential, open probability, gating kinetics)surrogate

Identified and characterized a Ca2+-activated non-selective cation channel in adult guinea-pig ventricular cells, which may contribute to transient inward currents in Ca2+-overloaded cardiac cells.

Cite This Study

Ehara et al. (1988) studied this question.

synapsesocial.com/papers/69f29ce01b51e2fbf01872b0https://doi.org/10.1113/jphysiol.1988.sp017242
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrical properties of individual cells isolated from adult rat ventricular myocardium.1980 · 396 citations
  2. 2The dependence of calcium efflux from cardiac muscle on temperature and external ion composition1968 · 1,025 citations
  3. 3Identification of sodium‐calcium exchange current in single ventricular cells of guinea‐pig.1987 · 630 citations
  4. 4Na-Ca exchange: stoichiometry and electrogenicity1985 · 259 citations