Systolic Improvement and Mechanical Resynchronization Does Not Require Electrical Synchrony in the Dilated Failing Heart With Left Bundle-Branch Block
Why the study?
Does left ventricular or biventricular pacing improve mechanical synchrony and function without requiring electrical synchrony in dogs with LBBB-failing hearts?
Population
Dogs with left bundle-branch block (LBBB)-failing hearts
Comparison
Left ventricular and Biventricular pacing vs Right atrial pacing-LBBB
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Mechanical coordination may drive CRT gains independent of electrical synchrony in LBBB-HF models; hypothesis-generating and leaves open human translation.
Structured PICO
Does left ventricular or biventricular pacing improve mechanical synchrony and function without requiring electrical synchrony in dogs with LBBB-failing hearts?
P
Population
Dogs with left bundle-branch block (LBBB)-failing hearts
I
Intervention
Left ventricular (LV) and Biventricular (BiV) pacing
C
Comparator
Right atrial pacing-LBBB
O
Outcome
Chamber hemodynamics (dP/dt(max) and aortic pulse pressure), mechanical resynchronization, and electrical dispersion measured by epicardial mapping, tagged MRI, and hemodynamicssurrogate
In a canine model of LBBB heart failure, mechanical coordination rather than electrical synchrony was found to be the primary driver of systolic improvement during LV or BiV pacing.
Cite This Study
Leclercq et al. (2002) studied this question.