Are circulating vascular biomarkers related to physiological indices of aortic stiffness and endothelial function in patients with hypertension?
Circulating glycocalyx markers are weakly associated with physiological vascular measures in hypertension, suggesting they may provide additional information but cannot replace physiological measurements.
. HA was independently related to cfPWV (β = 0.23, P = 0.02), whereas SDC-1 was independently inversely related to skin microvascular function, (β= - 0.27, P = 0.042) and was independently related to resistance artery endothelial function (β = 0.29, P = 0.026). All circulating biomarkers were unrelated to physiologically measured large artery endothelial function, and with echocardiographic parameters. The glycocalyx markers were associated with physiological vascular measures independent of eGFR but should not be considered as a proxy for these measures, due to the weak relations. However, combining circulating markers with physiological measures might give additional information about vascular function.
Jekell et al. (Tue,) studied this question.
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