Complexation improves solubility of C70 in aqueous solution, indicating potential applications in pharmaceuticals.
We investigated the solubilizing effects of cyclomaltononaose (δ-CD), a cyclic oligosaccharide composed of nine α-1,4-linked D-glucose units, on C70 by using the ball-milling method based on a solid-solid mechanochemical reaction. The complex between C70 and δ-CD was characterized by UV-VIS spectrometry and fast atom bombardment mass spectrometry (FAB-MS). Coloration of the C70/δ-CD system was red-brown in aqueous solution, and the UV-VIS spectrum was in agreement with that of C70 in hexane solution. The FAB-MS spectrum of the C70/δ-CD system showed a negative ion peak corresponding to the molecular weight of a complex between two δ-CD and one C70. These findings suggest that the solubilization of C70 in water was due to complex formation of C70 with δ-CD, and the stoichiometric ratio of this complex was 1 : 2 (C70 : δ-CD).
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Furuishi et al. (2008) studied this question.
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