Abstract Background/Aims Herpes zoster (HZ) is a common infection, particularly in older adults and women, and can lead to complications like neuropathic pain. The risk is higher in immunosuppressed individuals. Shingrix, a recombinant subunit vaccine, has proven effective in reducing HZ risk by stimulating robust CD4 and CD8 T-cell responses. However, data on its immunogenicity in patients with immune-mediated inflammatory diseases (IMIDs) remains limited. This study aimed to evaluate B-cell and T-cell immune responses to the recombinant HZ vaccine in IMID patients treated with JAK inhibitors (JAK-i), anti-TNF therapies, or methotrexate (MTX), and to identify factors associated with reduced vaccine-induced immunity. Methods This study investigated both humoral and cellular immune responses following a two-dose regimen of the recombinant inactivated vaccine in 131 patients with IMIDs treated with JAK-i, anti-TNF therapy, or MTX. The results were compared to those of 27 healthy controls matched for age and sex. Cellular immune responses were assessed through CD4 + (Th1) and CD8 + (cytotoxic) T-cell activation, while VZV-specific IgG antibody levels were used to evaluate humoral responses. Results Among 157 participants (mean age 58.2 years), JAK-i users had significantly lower immune responses. Seroconversion was 86% in JAK-i patients, compared to 97% in anti-TNF/MTX and 100% in controls (P = 0.03). VZV IgG titres were significantly lower in the JAK-i group (mean 1842 U/mL) versus anti-TNF/MTX and controls (both ∼3,000 U/mL, P 0.0001). Only 28% of JAK-i patients had a full CD4+ Th1 response (vs. 74% anti-TNF/MTX, 93% controls), and CD8+ responses were similarly reduced (29% vs. 42% and 85%, respectively). Immunogenicity was negatively associated with cumulative MTX and glucocorticoid use, prior DMARDs, baricitinib and tofacitinib treatment, and longer JAK-i exposure. A positive correlation was seen between CD4+ and CD8+ responses (β = 0.36, P = 0.0002). Conclusion IMID patients treated with JAK inhibitors exhibit significantly reduced humoral and cellular immune responses to the HZ recombinant vaccine, suggesting lower protection against VZV reactivation. While some reduction was seen in the anti-TNF/MTX group, their immune responses remained relatively preserved. The findings underscore the impact of JAK inhibitors and cumulative immunosuppression on vaccine efficacy in this population.). Disclosure C. Sieiro Santos: None. J. Garcia Herrero: None. J. Ordas Martínez: None. R. Colindres: None. J. Ruiz de Morales: None.
Santos et al. (Wed,) studied this question.