Study demonstrates successful separation of beta2-agonists in high performance liquid chromatography, suggesting ionic interactions play a key role.
The enantiomeric resolution of six β2-agonists including bambuterol, clenbuterol, clenproperol, fumoterol, mabuterol and terbutaline, was studied on three macrocyclic antibiotic chiral stationary phases (CSPs): Chirobiotic V, T and R. By varying the mobile phase compositions for different CSPs, all the six compounds were successfully separated on Chirobiotic V and T CSPs. The thermodynamic parameter variation was calculated. The chiral recognition mechanism was discussed, the ionic interaction was confirmed to be the most dramatic interaction responsible for the chiral recognition. No enantiosepartion for all the β2-agonists was found on Chirobiotic R CSP.
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Zhang et al. (2007) studied this question.
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