Findings reveal evolutionary links between nitrogen, carbon, and sulfur cycles through L-cluster-bound configurations.
-like enzyme that preceded the modern, high-efficiency two-component system; whereas the shared L-cluster topology found in ancient nondiazotrophic enzymes like methyl-CoM reductase and methylthio-alkane reductase further implies that the L-cluster may represent an evolutionary link among nitrogen, carbon, and sulfur biogeochemical cycles.
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Quechol et al. (2026) studied this question.
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