Pectic polysaccharides reduce ulcerative colitis severity in mouse models, suggesting anti-inflammatory effects may stem from increased IκB-α expression.
The therapeutic potential of pectic polysaccharides extracted from Rauvolfia verticillata (Lour.) Baill. var. hainanensis Tsiang in ulcerative colitis were investigated. This study showed that pectic polysaccharides extracted from Rauvolfia verticillata (Lour.) Baill.var.hainanensis Tsiang ameliorated ulcerative colitis and were proposed to exhibit anti-inflammatory effects via increased expression of IκB-α proteins and suppressing NF-αB translocation.
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Miao et al. (2015) studied this question.
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