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April 30, 2026Lara D. Veeken

E126 Unmasking lymphoma predictors in Sjögren disease: a 40-year follow-up cohort

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Authors

MAMònica Angerri-NadalUCUxía Couto-LareoBVBlanca Viejo-Sosa

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Overview

Retrospective cohort reveals lymphoma risk factors in Sjögren disease, highlighting hypergammaglobulinemia and parotid swelling.

Key Points

  • This study aims to evaluate lymphoma prevalence and risk factors in a Sjögren disease cohort over 40 years.
  • Retrospective observational design involving patients meeting 2016 ACR/EULAR Sjögren disease criteria
  • Demographic, clinical, and serological data collected from hospital records
  • Statistical analysis using Chi-square, Fisher’s exact tests, and relative risk calculations
  • Lymphoma prevalence was identified at 9.9%, primarily non-Hodgkin MALT type
  • Significant predictors included hypergammaglobulinemia (RR = 2.56, p = 0.03) and parotid swelling (RR = 5.53, p < 0.001)
  • Overall mortality rate was 18.6%, with some deaths attributed to lymphoma.

Cite This Study

Angerri-Nadal et al. (2026) studied this question.

synapsesocial.com/papers/69f2a4b78c0f03fd67763b65https://doi.org/10.1093/rheumatology/keag121.348
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