Administration of prednisolone showed drug concentrations of 95 ng/ml in cochlea after 15-25 mins, indicating significant absorption in patients with perilymph fistula.
After iv administration of 200 mg prednisolone in patients with perilymph fistula, concentrations of the drug in the cochlea were determined. A specially adapted LC method was used for analysis. Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15–25 min, and 338 ng/ml after 30–45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively.
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Oertel et al. (2007) studied this question.
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